KIDS HAVE STROKES
Sickle Cell Anemia and Stroke in Children
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Sickle cell anemia is an inherited, chronic disease in which the red blood cells, normally disc-shaped, become crescent shaped. As a result, they function abnormally and break down, causing recurrent painful episodes.
Sickle cell anemia is caused by an abnormal type of hemoglobin (oxygen carrying pigment) called hemoglobin S. It is inherited as an autosomal recessive trait; that is, it occurs in someone who has inherited hemoglobin S from both parents.
From the medical college of Georgia (2003):
Of the 2000 children with Sickle Cell Disease born in the United States each year, about 10 percent will develop stroke by adulthood.
Stroke in children and sickle-cell disease Baltimore-Washington Cooperative Young Stroke Study
Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia. April 2005, Boston.
Sickle cell disease: primary stroke prevention. June 2004. Georgia.
Brain imaging findings in pediatric patients with sickle cell disease. July 2003. Tennessee.
Stroke risk in siblings with sickle cell anemia, March 2003, multicenter study.
Sickle Cell Disease in Childhood: Part I. Laboratory Diagnosis, Pathophysiology and Health Maintenance Doris Wethers, M.D., St. Luke's-Roosevelt Hospital Center, NY, NY
Sickle Cell Disease in Childhood: Part II. Diagnosis and Treatment of Major Complications and Recent Advances in Treatment Doris Wethers, M.D., St. Luke's-Roosevelt Hospital Center, NY, NY
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